2014 Lyme & Tick-Borne Diseases:
Medical, Neuropsychiatric & Public Health Implications

Providence Downtown Marriott

Providence, RI

May 3-4, 2014

Current/Recent Research Studies

Current Studies In Progress

Please check back soon for current studies.

Recent Completed Studies

  • "Lyme Disease Community Blood Screening Study"
    • Principal Investigator: Brian Fallon, MD
    • Goals: To develop a national resource specimen bank for diagnostic test and biomarker development
    • Design: Patients will be screened in Lyme endemic areas and at the Columbia Lyme and Tick-Borne Diseases Research Center
    • Benefit: Patients will receive a copy of the Lyme C6 ELISA test result
    • Eligibility: Patients age 18-75 with clinical features of Lyme disease at all stages of illness
    • Funding: Lyme and Tick-Borne Diseases Research Center Gift Funds, Oxford Immunotec Ltd, Time for Lyme, Inc
    • Status:  Summer '09 screening clinics have been completed. 

  • “Proteomic Studies of CSF of patients with neurologic Lyme disease”
    • Principal Investigator: Steven Schuzter, MD, UMDNJ  
    • Goals: to identify novel proteins in CSF of Lyme patients
    • Design: the CSF of patients with chronic neurologic Lyme disease will be compared to the CSF of individuals without a known neurologic disease.  This study involves collaboration with several research groups.
    • Funding: Lyme Disease Association, Inc and Time for Lyme, Inc.
    • Status: study completed
    • How to learn more: read article "Distinct Cerebrospinal Fluid Proteomes Differentiate Post-Treatment Lyme Disease from Chronic Fatigue Syndrome" in PLoS ONE
  • “Brain SPECT Imaging in Chronic Lyme Disease”
    • Principal Investigator:  Brian Fallon, MD
    • Goals: to determine the clinical usefulness of Brain SPECT imaging when performed for clinical differential diagnosis in a patient with a history of Lyme disease.
    • Design: patients with a history of Lyme disease and volunteers without a history of Lyme disease had a brain SPECT.  Scans were read by experts in nuclear medicine blind to diagnosis.
    • Funding: Lyme Disease Association, Inc, and National Research Fund for Lyme and Tick-Borne Diseases.
    • Status:  Data collection has been completed. Analysis is ongoing.
    • How to learn more:  study is closed for participation.
  • “Brain Imaging and Treatment of Persistent Lyme Encephalopathy”
    • Principal Investigator:  Brian Fallon, MD
    • Goals: to clarify the structural and metabolic abnormalities in the central nervous system of patients with chronic cognitive deficits and to evaluate the efficacy of 10 weeks of IV antibiotic therapy among these patients all of whom had received prior IV treatment
    • Funding: National Institutes of Health (National Institute of Neurological Disorders and Stroke)
    • Status: study completed. Additional papers in progress.
    • How to learn more:
    • See Featured Research (provide link)
    • Read the following articles:
    • Fallon BA, Keilp JG, Corbera KM et al: “A Randomized, Placebo-Controlled Trial of  Repeated IV Antibiotic Therapy for Lyme Encephalopathy.”  Neurology (2008; 70 (13); 992-1003)
    • Keilp JG, Corbera KM, Slavov I et al: “WAIS-III and WMS-III performance in chronic Lyme disease J International Neuropsychological Society. 2006;12(1):119-129.
    • Fallon BA, Lipkin RB, Corbera KM et al: “Regional Cerebral Blood Flow and Metabolic Rate in Persistent Lyme Encephalopathy. Arch Gen Psychiatry. 2009;66(5):554-563.

  • Laboratory Testing in Chronic Lyme Disease”
    • Principal Investigator:   Brian Fallon, MD
    • Goals: to determine whether Lyme Specialty Labs were better able to identify patients with CLD from non-Lyme controls and to determine which tests had the best sensitivity/specificity balance
    • Design:  Serum was drawn from the two groups of participants.  Serum from each patient was sent to 4 labs (1 University Based Lyme Lab, 2 Private labs with a Lyme Specialty, and 1 National Commercial Lab).  Samples were tests for ELISA, C6 ELISA, IgM Western blot, IgG Western blot.  When available, both the CDC and the lab’s own internal criteria were used for blot interpretation.
    • Funding:  Time for Lyme, Inc.
    • Status: Study closed for enrollment. Data collection and analyses are completed. Paper is being prepared for publication.

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