Current Research Studies

  • Why do some individuals continue to experience chronic symptoms of Lyme Disease, such as pain, fatigue, sensory hypersensitivity, and neurocognitive difficulties long after receiving treatment? Through the use of brain imaging (functional MRI) and specific biomarker testing, we hope to gain a better understanding as to why patients develop this persistent, debilitating pain. Based on prior research, we suspect that Lyme disease may change the pattern of an individual's brain activation, making him or her more sensitive to pain than a healthy person.
  • Are you suffering from chronic fatigue that began after you were diagnosed and treated with antibiotics for Lyme Disease? This new treatment research study investigates whether disulfiram, commonly known as "Antabuse", has the potential to be used as a treatment option for patients experiencing chronic post-treatment Lyme symptoms. This well-known, FDA approved drug is currently used to help individuals with alcohol dependence resist consumption; however, new scientific research has demonstrated that disulfiram is a potent killer of the Lyme bacteria in the laboratory setting.
  • Why do some patients recover quickly after Lyme disease while others develop chronic symptoms? To answer this question, we need to enroll patients at different stages of illness -- early at the initial infection when it affects the skin, joints, nervous system or heart, and later as well to see who has recovered and who has persistent symptoms. Some have only a mild illness associated with the rash. Others are quite ill and may not be sure when they were infected. We follow each patient carefully over 2 years.
  • This long-term goal in this study is to reduce the number of patients who develop symptoms of chronic Lyme disease (also known as Post-treatment Lyme Syndrome) by identifying better tests and by understanding the immunologic, rheumatologic, and neurologic impact of this illness over time. This can only be done by comparing those patients who recover fully to those who experience ongoing symptoms, as well as to healthy controls. While at the Center, we will collect blood and conduct very careful clinical assessments.
  • The CDC estimates that 10-20% of patients with Lyme disease will go on to have chronic symptoms despite having had appropriate treatment, a condition known as Post-Treatment Lyme Disease Syndrome (PTLDS). While there is currently no known cure, various therapies are being investigated. One promising approach is the practice of meditation and yoga which have been shown to help pain and fatigue associated with other chronic illnesses as well as to improve overall physical, mental, and emotional health.
  • We are recruiting healthy volunteers to participate in our diagnostic brain imaging study. This new study aims to investigate individuals experiencing persistent pain that was triggered by Lyme Disease. By utilizing brain imaging (functional MRI), we hope to gain a better understanding of why patients have ongoing problems with persistent pain, fatigue, and sensory sensitivity even after antibiotic treatment. We suspect that Lyme disease may change the pattern of an individual's brain activation, making him or her more sensitive to pain than a healthy person.